Determining Carotid Pulse Wave Velocity in Dogs with Canine Cognitive Dysfunction by Doppler Ultrasonography

Abstract

A neurodegenerative condition affecting geriatric dogs is called “canine cognitive dysfunction”, (CCD) a disease that is similar to Alzheimer’s disease in many aspects. Vascular risk factors have been implicated in the development of all-cause dementia and Alzheimer’s disease in humans. The purpose of this study was to determine the carotid pulse wave velocity in CCD dogs by Doppler ultrasonography and compare with normal dogs. Carotid ultrasonography was done on 17 CCD dogs that were positive base on CCD rating scale. One way ANOVA (post-hoc Scheffe) was used to compare the velocities among the vessels.

Mean values of RI and PI in CDS(cognitive dysfunction syndrome) positive dogs were more than those of CDS negative dogs and the mean values of PSV, EnDV and MV in CDS positive dogs were less than those of CDS negative dogs. But there was no significant association between the values of carotid pulse wave velocity among CDS positive and negative doges. However, the results of this study may be useful as a baseline data for future investigations.