Effect Of Surfactant Chain Length Difference In Mixed Surfactant Systems On Self Emulsification Of Poorly Soluble Drug
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Abstract
In the present investigation the effect of chain length difference (Δn) of different surfactant mixtures was evaluated on self emulsifying capability of self emulsifying drug delivery system of aceclofenac. Three surfactants of Tween series namely Tween 20, Tween 40 and Tween 80 were used for the study. The lipid carrier used was almond oil. Surfactant mixtures were prepared by combining Tween 20 and Tween 80 (Δn=6), Tween 20 and Tween 40 (Δn=4), Tween 40 and Tween 80 (Δn=2) in definite proportion. Pseudoternary diagram study was carried out to determine the surfactant mixture which provides the largest microemulsifying region. The pseudoternary diagram study revealed that the microemulsifying region increases as the difference in chain length increases. So, Tween 80 and Tween 20 were selected for formulation development, the proportion of which is further optimized by simplex lattice design. The formulations were prepared and subjected to different evaluation parameters. The optimized formulation has a particle size of 68.95 nm and zeta potential of -15.3 mV.
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References
Balakumar K, Raghavan CV, Selvan NT, Rahman SMH. Self emulsifying drug delivery system :
Optimization and its prototype for various compositions of oils , surfactants and. JOPR J Pharm Res
[Internet]. 2013;6(5):510–4. Available from: http://dx.doi.org/10.1016/j.jopr.2013.04.031
Bernkop-schnürch A, Jalil A. NU. J Control Release [Internet]. 2017; Available from:
http://dx.doi.org/10.1016/j.jconrel.2017.12.027
Echeverry SM, Rey D, Valderrama IH, Araujo BV de, Aragón DM. Development of a self-emulsifying
drug delivery system (SEDDS) to improve the hypoglycemic activity of Passiflora ligularis leaves
extract. J Drug Deliv Sci Technol. 2021;64(January).
Bnyan R, Khan I, Ehtezazi T, Saleem I, Gordon S, O’Neill F, et al. Surfactant Effects on Lipid-Based
Vesicles Properties. J Pharm Sci [Internet]. 2018;107(5):1237–46. Available from:
https://doi.org/10.1016/j.xphs.2018.01.005
Schreier S, Malheiros SVP, De Paula E. Surface active drugs: Self-association and interaction with
membranes and surfactants. Physicochemical and biological aspects. Biochim Biophys Acta -
Biomembr. 2000;1508(1–2):210–34.
Schulz PC, Rodríguez JL, Minardi RM, Sierra MB, Morini MA. Are the mixtures of homologous
surfactants ideal? J Colloid Interface Sci. 2006;303(1):264–71.
Groth C, Nydén M, Holmberg K, Kanicky JR, Shah DO. Kinetics of the self-assembly of gemini
surfactants. J Surfactants Deterg. 2004;7(3):247–55.
Mahdi ES, Sakeena MH, Abdulkarim MF, Abdullah GZ, Sattar MA, Noor AM. Effect of surfactant and
surfactant blends on pseudoternary phase diagram behavior of newly synthesized palm kernel oil esters.
Drug Des Devel Ther. 2011;5:311–23.
Szymczyk K, Zdziennicka A, Jańczuk B. Adsorption and Aggregation Properties of Some Polysorbates
at Different Temperatures. J Solution Chem [Internet]. 2018;47(11):1824–40. Available from:
https://doi.org/10.1007/s10953-018-0823-z
Zhang H, Feng F, Li J, Zhan X, Wei H, Li H, et al. Formulation of food-grade microemulsions with
glycerol monolaurate: Effects of short-chain alcohols, polyols, salts and nonionic surfactants. Eur Food
Res Technol. 2008;226(3):613–9.
Chai JL, Liu N, Bai TT, Zhang HM, Liu NN, Wang D. Compositions and Physicochemical Properties of
Tween Type Surfactants-Based Microemulsions. J Dispers Sci Technol. 2014;35(3):441–7.
Maulvi FA, Desai AR, Choksi HH, Patil RJ, Ranch KM, Vyas BA, et al. Effect of surfactant chain
length on drug release kinetics from microemulsion-laden contact lenses. Int J Pharm [Internet].
;524(1–2):193–204. Available from: http://dx.doi.org/10.1016/j.ijpharm.2017.03.083
Chouhan S, Chauhan LS. Effect Of Surfactant Chain Length On Emulsification Dynamics Of Self
Emulsifying Formulation Of Poorly Soluble Drug. Curr Drug Deliv. 2021;18:1–15.
Yan B, Ma Y, Guo J, Wang Y. Self-microemulsifying delivery system for improving bioavailability of
water insoluble drugs. J Nanoparticle Res. 2020;22(1).
Yang JH, Suk KS, Lee BH, Jung WC, Kang YM, Kim JH, et al. Efficacy and safety of different
aceclofenac treatments for chronic lower back pain: Prospective, randomized, single center, open-label
clinical trials. Yonsei Med J. 2017;58(3):637–43.
Liu Y, Liu M, Yan H, Liu H, Liu J, Zhao Y, et al. Enhanced solubility of bisdemethoxycurcumin by
interaction with Tween surfactants: Spectroscopic and coarse-grained molecular dynamics simulation
studies. J Mol Liq [Internet]. 2021;323:115073. Available from:
https://doi.org/10.1016/j.molliq.2020.115073
Jianxian C, Saleem K, Ijaz M, Ur-Rehman M, Murtaza G, Asim MH. Development and in vitro
evaluation of gastro-protective aceclofenac-loaded self-emulsifying drug delivery system. Int J
Nanomedicine. 2020;15:5217–26.
Atef E, Belmonte AA. Formulation and in vitro and in vivo characterization of a phenytoin selfemulsifying drug delivery system (SEDDS). Eur J Pharm Sci. 2008;35(4):257–63.
Balakrishnan P, Lee BJ, Oh DH, Kim JO, Lee YI, Kim DD, et al. Enhanced oral bioavailability of
Coenzyme Q10 by self-emulsifying drug delivery systems. Int J Pharm. 2009;374(1–2):66–72.
Prajapat MD, Patel NJ, Bariya A, Patel SS, Butani SB. Formulation and evaluation of self-emulsifying
drug delivery system for nimodipine, a BCS class II drug. J Drug Deliv Sci Technol [Internet].
;39(October 2018):59–68. Available from: http://dx.doi.org/10.1016/j.jddst.2017.02.002
Das SS, Singh A, Kar S, Ghosh R, Pal M, Fatima M, et al. Application of QbD Framework for
Development of Self-Emulsifying Drug Delivery Systems [Internet]. Pharmaceutical Quality by Design.
Elsevier Inc.; 2019. 297–350 p. Available from: http://dx.doi.org/10.1016/B978-0-12-815799-2.00015-0
Hosny KM, Al Nahyah KS, Alhakamy NA. Self-Nanoemulsion Loaded with a Combination of
Isotretinoin, an Anti-Acne Drug, and Quercetin: Preparation, Optimization, and In Vivo Assessment.
Pharmaceutics. 2020;13(1):46.
Salawi A. Self-emulsifying drug delivery systems: a novel approach to deliver drugs. Drug Deliv
[Internet]. 2022;29(1):1811–23. Available from: https://doi.org/10.1080/10717544.2022.2083724
Utami D, Meliana Y, Helmiyati, Budianto E. In-Vitro Dissolution and Characterization of SelfEmulsifying Drug Delivery System of Artemisinin for Oral Delivery. J Phys Conf Ser. 2021;
Zewail MB, El-Gizawy SA, Osman MA, Haggag YA. Preparation and In vitro characterization of a
novel self-nano emulsifying drug delivery system for a fixed-dose combination of candesartan cilexetil
and hydrochlorothiazide. J Drug Deliv Sci Technol [Internet].2021;61(November 2020):102320.
Bennett-Lenane H, Jørgensen JR, Koehl NJ, Henze LJ, O’Shea JP, Müllertz A, et al. Exploring porcine
gastric and intestinal fluids using microscopic and solubility estimates: Impact of placebo self-emulsifying drug delivery system administration to inform bio-predictive in vitro tools. Eur J Pharm Sci.
;161(February).
Shewaiter MA, Hammady TM, El-Gindy A, Hammadi SH, Gad S. Formulation and characterization of
leflunomide/diclofenac sodium microemulsion base-gel for the transdermal treatment of inflammatory
joint diseases. J Drug Deliv Sci Technol [Internet]. 2021;61(July):102110. Available from:
https://doi.org/10.1016/j.jddst.2020.102110
Ansari MJ, Alnakhli M, Al-Otaibi T, Meanazel O Al, Anwer MK, Ahmed MM, et al. Formulation and
evaluation of self-nanoemulsifying drug delivery system of brigatinib: Improvement of solubility, in
vitro release, ex-vivo permeation and anticancer activity. J Drug Deliv Sci Technol [Internet].
;102204. Available from: https://doi.org/10.1016/j.jddst.2020.102204
Manish Upadhyay, Vijay Ghori, M.M. Soniwala. Design And Optimization of Midazolam Loaded
Microemulsion Using Quality by Design (Qbd) Assisted Statistical Modelling. J Pharm Negat Results.
;13(9):765–76.
Bhattacharya S. Double w/o/w self-nano emulsifying drug delivery system of imatinib mesylate for
colon cancer treatment. J Mol Liq [Internet]. 2021;341:117368. Available from:
https://doi.org/10.1016/j.molliq.2021.117368
Gibaud S, Attivi D. Microemulsions for oral administration and their therapeutic applications. Expert
Opin Drug Deliv. 2012;9(8):937–51.
Geethanjali K, Vaiyana RC. Formulation and evaluation of self nano-emulsifying drug delivery system
of ezetimibe for dissolution rate enhancement. Int J Res Pharm Sci. 2020;11(2):1294–301.
Cao M, Zhan M, Wang Z, Wang Z, Li XM, Miao M. Development of an orally bioavailable
isoliquiritigenin self-nanoemulsifying drug delivery system to effectively treat ovalbumin-induced
asthma. Int J Nanomedicine. 2020;15:8945–61.
Banik S, Halder S, Sato H, Onoue S. Self-emulsifying drug delivery system of (R)-α-lipoic acid to
improve its stability and oral absorption. Biopharm Drug Dispos. 2021;42(5):226–33.
Batool A, Arshad R, Razzaq S, Nousheen K, Kiani MH, Shahnaz G. Formulation and evaluation of
hyaluronic acid-based mucoadhesive self nanoemulsifying drug delivery system (SNEDDS) of
tamoxifen for targeting breast cancer. Int J Biol Macromol [Internet]. 2020;152:503–15.
Dizdarević A, Marić M, Shahzadi I, Ari Efiana N, Matuszczak B, Bernkop-Schnürch A. Imine bond
formation as a tool for incorporation of amikacin in self-emulsifying drug delivery systems (SEDDS).
Eur J Pharm Biopharm. 2021;162(February):82–91.
Abdulkarim M, Sharma PK, Gumbleton M. Self-emulsifying drug delivery system: Mucus permeation
and innovative quantification technologies. Adv Drug Deliv Rev [Internet]. 2019;142:62–74. Available
from: https://doi.org/10.1016/j.addr.2019.04.001
De M, Bhattacharya SC, Moulik SP, Panda AK. Interfacial composition, structural and thermodynamic
parameters of water/(surfactant+n-butanol)/n-heptane water-in-oil microemulsion formation in relation
to the surfactant chain length. J Surfactants Deterg. 2010;13(4):475–84.
Laddha P, Suthar V, Butani S. Development and optimization of self microemulsifying drug delivery of
domperidone. Brazilian J Pharm Sci. 2014;50(1):91–100.
Rasoanirina BNV, Lassoued MA, Kamoun A, Bahloul B, Miladi K, Sfar S. Voriconazole-loaded selfnanoemulsifying drug delivery system (SNEDDS) to improve transcorneal permeability. Pharm Dev
Technol [Internet]. 2020;25(6):694–703. Available from:
http://dx.doi.org/10.1080/10837450.2020.1731532
Zhang X, Meng L, Lu Q, Fei Z, Dyson PJ. Targeted delivery and controlled release of doxorubicin to
cancer cells using modified single wall carbon nanotubes. Biomaterials [Internet]. 2009;30(30):6041–7.
Lupo N, Jalil A, Nazir I, Gust R, Bernkop-Schnürch A. In vitro evaluation of intravesical mucoadhesive
self-emulsifying drug delivery systems. Int J Pharm [Internet]. 2019;564(January):180–7. Available
from: https://doi.org/10.1016/j.ijpharm.2019.04.035
Izham MNM, Hussin Y, Aziz MNM, Yeap SK, Rahman HS, Masarudin MJ, et al. Preparation and
characterization of self nano-emulsifying drug delivery system loaded with citraland its antiproliferative
effect on colorectal cells in vitro. Nanomaterials. 2019;9(7).
Wolf JD, Kurpiers M, Götz RX, Zaichik S, Hupfauf A, Baecker D, et al. Phosphorylated PEGemulsifier: Powerful tool for development of zeta potential changing self-emulsifying drug delivery
systems (SEDDS). Eur J Pharm Biopharm [Internet]. 2020;150(March):77–86. Available from:
https://doi.org/10.1016/j.ejpb.2020.03.004
Madan JR, Patil K, Awasthi R, Dua K. Formulation and evaluation of solid self-microemulsifying drug
delivery system for azilsartan medoxomil. Int J Polym Mater Polym Biomater [Internet].2021;70(2):100–16. Available from: https://doi.org/10.1080/00914037.2019.1695206
Gao Y, Lei Y, Wu Y, Liang H, Li J, Pei Y, et al. Beeswax: A potential self-emulsifying agent for the
construction of thermal-sensitive food W/O emulsion. Food Chem [Internet].
;349(January):129203.
Fan Q, Zhao R, Yi M, Qi P, Chai C, Ying H, et al. Ti3C2-MXene composite films functionalized with
polypyrrole and ionic liquid-based microemulsion particles for supercapacitor applications. Chem Eng J
[Internet]. 2021;428(May 2021):131107. Available from: https://doi.org/10.1016/j.cej.2021.131107
Trawińska A, Hallmann E, Mędrzycka K. The effect of alkyl chain length on synergistic effects in
micellization and surface tension reduction in nonionic gemini (S-10) and anionic surfactants mixtures.
Colloids Surfaces A Physicochem Eng Asp [Internet]. 2016;506:114–26. Available from: