THE USE OF OZONE THERAPY IN THE COMPLEX TREATMENT OF FLAT-SHAPED LEUKOPLAKIA OF THE ORAL MUCOSA

Abstract

Leukoplakia is an orogenesis of the oral mucosa and red karma of the lips, accompanied by inflammation, which occurs, as a rule, in response mainly to chronic exogenous irritation, without denying the influence of endogenous factors (A.A.Bezrukov, 2018; E.A.Gaibullaev, L. Chau et al, 2022).            Clinically, there are flat, verricose, erosive-ulcerative, smokers' leukoplakia (Toppeiner), simple and mild forms of leukoplakia.Leukoplakia of the oral mucosa belongs to facultative precancers, the degree of probability and frequency of malignancy of which are not clearly defined and according to cancer studies vary from 12 to 25% (O.F.Rabinovich et al., 2022; M.A.Nivech, 2010; J. Lodi et al, 2016).Therefore, the identification of early stages of pathogenetic features of the development of oral leukoplakia and timely adequate treatment is of great importance for the prevention of oncological degeneration of this disease.Meanwhile, in recent years, non-drug therapies, one of which is ozone therapy, have attracted great attention of scientists and practitioners.To date, studies related to the use of general and local ozone therapy in the complex treatment of flat-shaped leukoplakia of the oral mucosa have not been conducted.The purpose of the ongoing study is to increase the effectiveness of treatment of patients with flat form of leukoplakia of the oral mucosa through the use of general and local ozone therapy