Formulation and Evaluation of Cabotegravir and Etravirine Tablets: A Factorial Study Incorporating Cyclodextrins and Tween 80
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Abstract
The study aimed to investigate the formulation and evaluation of Cabotegravir and Etravirine tablets by incorporating cyclodextrins (β-CD and HPβ-CD) and Tween 80. The results revealed that the inclusion of cyclodextrins and Tween 80 had a significant impact on the characteristics of the tablets. In terms of drug content, The Cabotegravir +HPβ-CD and β-CD formulation exhibited slightly higher drug content percentages (97.42±1.03 to 96.12±1.01). Similarly, the tablets formulated with Etravirine HPβ-CD and β-CD exhibited slightly higher drug content percentages (99.78±2.12 to 99.23±1.25). The Cabotegravir +HPβ-CD and β-CD formulation exhibited slightly higher dissolution percentages, ranging from 54.46±0.43 and 53.03±1.26. In the case of the Etravirine HPβ-CD and β-CD formulation, the dissolution percentages ranged from 94.52±3.41 to 93.23±1.21. Overall, this factorial study successfully optimized the formulation of Cabotegravir and Etravirine tablets by incorporating cyclodextrins and Tween 80. The results highlight the importance of these excipients in achieving desirable drug content, dissolution profiles, and tablet properties. This research provides valuable insights for the development of improved antiretroviral drug formulations, potentially enhancing the therapeutic outcomes for individuals affected by HIV infections.
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