Formulation And Characterization Of Buccal Patches Of Dapagliflozin Using Box–Behnken Design
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Abstract
Buccal drug delivery has emerged as a promising approach for the systemic delivery of various therapeutic agents, offering several advantages over conventional oral administration routes (Dhiman et al., 2020). Buccal patches, in particular, provide controlled release of drugs, enhanced bioavailability, avoidance of hepatic first-pass metabolism, and improved patient compliance. Dapagliflozin, a selective sodium-glucose co-transporter 2 (SGLT2) inhibitor, is widely used in the management of type 2 diabetes mellitus.
Formulation and characterization of buccal patches of dapagliflozin represent a novel strategy to enhance drug delivery and therapeutic efficacy. The development of optimized buccal patches can address challenges associated with the oral administration of dapagliflozin, such as variable absorption, gastrointestinal side effects, and dosing frequency.
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References
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