EVALUATION OF GLUTATHIONE REDUCTASE (GR) ACTIVITY IN LIVER OF FISH, CHANNA PUNCTATUS (BLOCH, 1793) EXPOSED TO HEXAVALENT CHROMIUM

Abstract

Antioxidant defence system is known to be a sensitive biomarker of metal exposure widely employed in predicting toxicity after sub-lethal exposure of Cr6+in fish. The present study conducted to assess the impact of Cr6+on Glutathione reductase (GR) activity in liver of fish, Channa punctatus. Fish were exposed to two different sub-lethal concentrations of Cr6+viz.,3.93 mg/L (5% of 96h LC50) (T1) and 7.85 mg/L (10% of 96h LC50) (T2) along with one control group without any toxicant exposure, for 15, 30 and 45 d. Results showa significant (p <0.05) increase in GR activity with an increase in dose and exposure period. This study emphasized the role of GR in monitoring of metal toxicity in aquatic regimes as an early warning tool.