Antibacterial Activity of Paracetamol, Trimethoprim/sulfamethoxazole, Azithromycin, and Ciprofloxacin

Abstract

Paracetamol have indirect antibiotic activity and are commonly coadministered with antimicrobial therapy. This study aimed to assess the synergistic effect of Paracetamol to with Azithromycin, Trimethoprim/sulfamethoxazole and Ciprofloxacin against salmonella and Escherichia coli. In this study, Ciprofloxacin, Trimethoprim/sulfamethoxazole and Azithromycin was mixed paracetamol against salmonella and Escherichia coli. The results showed that the interaction between Paracetamol and Azithromycin, Trimethoprim/sulfamethoxazole and ciprofloxacin exhibited more in inhibitory potency against on Gram-negative salmonella and Escherichia coli. The combinations of Paracetamol with the Azithromycin and Trimethoprim/sulfamethoxazole showed significant inhibitory activity on the salmonella and Escherichia coli comparing to the inhibition activity showed from the tested antibiotics alone.