MORPHOLOGICAL AND MORPHOMETRIC PARAMETERS OF THE ESOPHAGUS OF WHITE OUTBRED RATS 3-6 MONTHS UNDER THE INFLUENCE OF THREE DIFFERENT ANTI-INFLAMMATORY DRUGS IN CONDITIONS OF POLYPHARMACY

Abstract

Nonsteroidal anti-inflammatory drugs (NSAIDs) are one of the most influential and widespread means of pathogenetic therapy for acute or chronic pain. However, NSAIDs have a specific adverse effect on the gastrointestinal tract. In recent years, the number of studies on damage to the esophagus due to NSAID use has increased. In this work, the morphological and morphometric parameters of the esophagus of 50 white outbred rats aged 3 to 6 months under the influence of 3 different anti-inflammatory drugs on polypharmacy were studied and analyzed.