Chemical Inhibition Of Integrase Enzyme Of Hiv

Abstract

HIV (human immunodeficiency virus) involves the presence of three enzymes in its life cycle:, viz Viral protease, reverse transcriptase, and Integrase. We have focused our study on inhibition of integrase enzyme, as its mutagenic tendencies are very low. Here we have synthesized drug molecules which have two pronged actions, one complexation of Mg2+ or Mn2+ ions with drug molecules as these ions act as cofactors for integrase enzymes, and the second action as regards to binding of drug molecules with human DNA, leading to conformational and configurational changes in it; thus, it becomes difficult for the viral DNA to integrate with human DNA.