Evaluating Safety And Efficiency Of Chemotherapy Among Patients With Advanced Colorectal Cancer

Abstract

AIM:

Evaluating safety and efficacy of chemotherapy among metastatic colorectal cancer patients The cultural, social, and religious differences in parenting and child-parent relationships in families make parenthood a sensitive domain for the research study. Accordingly, the changing

nature of families, culture, and gender discrimination influence or affect parenting styles and

parent-child relationships. The current study explored the conceptual understanding of parenthood, such as beliefs, views, expectations, and parental well-being in Indian families, especially in the states of Tamil Nadu, Kerala, and Gujarat. The participants were nine parents living together and with children the age range between eighteen and thirty-five. The parents’ age ranged from 41 to 63 (M = 50.8 years, SD = 6.05) (Mother’s age M = 48.7 years, SD = 6.04; Fathers’ age M = 52.9 years, SD = 5.28). They were selected based on purposive sampling. The method had an exploratory and qualitative design with multiple case studies. The researcher conducted in-depth, open-ended, semi-structured interviews using the online platform Google Meet and Zoom and face-to-face meetings. The interview transcriptions were analyzed using Braun and Clarke's inductive thematic analysis. The resulting six themes were:

Objectives:

Primary objective: To determine objective response rate of MCRC patients with chemotherapeutic regimen assessed as complete/ partial response/ stable/ progressive disease according to RECIST version 1.1. to evaluate the efficacy of chemotherapeutic regimen with in terms of objective response in accordance with response evaluation criteria in solid tumors RECIST version1.1.

Secondary objective: To asses patient’s performance status using ECOG scale and to estimate percentage of all grade toxicities in accordance with CTCAE version 4.03.

MATERIAL AND METHODS:

It is a retrospective single centered empirical study conducted at the medical record department of oncology at a tertiary hospital for the duration of 6 months.

CONCLUSION:

MCRC is one of the major cause of death globally as the treatment involves complexities alongside much complications with chemotherapy are seen together with better outcomes. Entire data comprises of 109 subjects diagnosed with MCRC recorded in this retrospective study among which the no. of Male patients were 80 and Female patients were 29. The information extracted from the above data was that male subjects of age group between 50-70Y were more effected with colorectal cancer than female subjects of age group 40-70Y and patient specific treatment response rates were determined. The study revealed efficacy of chemotherapeutic regimen was found more with capox (capecitabine) and it came out as the most trending treatment among folfox (fluorouracil, oxaliplatin) and folfirinox (fluorouracil, irinotecan, oxaliplatin and capox is widely preferred by oncologists. Study revealed that among 109 patients with mcrc, the patients of age group 40- 70Y were more effected with repeatedly occurring adverse events of chemotherapy using CTCAE and determining the patient activity status.