Insights Into Hepatitis Pathogenesis, Host Interactions And Genotypes

Main Article Content

Basma Ibrahim
Anas Bashir
Abdulaziz Al-Jehani
Ahmad Rajab
Ammar Al-Shaar
Zeyad Al-Farsi
Wesam Darra
Jawad Al-Hasan
Ammar Al-Saadawi
Anas Jarb

Abstract

Hepatitis is a global public health challenge that affects millions of people worldwide. It is an inflammation of the liver that can be caused by various factors, including viral infections, alcohol consumption, and certain medications or toxins. Viral hepatitis is of particular concern as it can lead to severe liver damage and potential life-threatening complications.


The World Health Organization recognizes five main types of viral hepatitis: hepatitis A, B, C, D, and E. Every type has distinct modes of transmission, clinical manifestations, and long-term consequences.


To address this public health issue, the World Health Organization has developed comprehensive strategies and guidelines for the prevention, control, and elimination of viral hepatitis. These strategies focus on increasing awareness, improving access to testing and treatment, implementing vaccination programs, promoting safe injection practices, and reducing the burden of viral hepatitis-related liver diseases.


Efforts to combat hepatitis also involve strengthening health systems, fostering international collaboration, and advocating for policy changes to ensure equitable access to prevention and treatment services for all individuals, regardless of their socioeconomic status or geographic location.

Downloads

Download data is not yet available.

Article Details

How to Cite
Basma Ibrahim, Anas Bashir, Abdulaziz Al-Jehani, Ahmad Rajab, Ammar Al-Shaar, Zeyad Al-Farsi, Wesam Darra, Jawad Al-Hasan, Ammar Al-Saadawi, & Anas Jarb. (2023). Insights Into Hepatitis Pathogenesis, Host Interactions And Genotypes. Journal of Advanced Zoology, 44(1), 129–140. https://doi.org/10.53555/jaz.v44i1.4419
Section
Articles
Author Biographies

Basma Ibrahim

Physiological Sciences Department- MBBS program, Fakeeh College for Medical Sciences, Jeddah 21461, Saudi Arabia

Anas Bashir

MBBS program, Fakeeh College for Medical Sciences, Jeddah 21461, Saudi Arabia

Abdulaziz Al-Jehani

Physiological Sciences Department- MBBS program, Fakeeh College for Medical Sciences, Jeddah 21461, Saudi Arabia

Ahmad Rajab

Physiological Sciences Department- MBBS program, Fakeeh College for Medical Sciences, Jeddah 21461, Saudi Arabia

Ammar Al-Shaar

Physiological Sciences Department- MBBS program, Fakeeh College for Medical Sciences, Jeddah 21461, Saudi Arabia

Zeyad Al-Farsi

Physiological Sciences Department- MBBS program, Fakeeh College for Medical Sciences, Jeddah 21461, Saudi Arabia

Wesam Darra

Physiological Sciences Department- MBBS program, Fakeeh College for Medical Sciences, Jeddah 21461, Saudi Arabia

Jawad Al-Hasan

Physiological Sciences Department- MBBS program, Fakeeh College for Medical Sciences, Jeddah 21461, Saudi Arabia

Ammar Al-Saadawi

Physiological Sciences Department- MBBS program, Fakeeh College for Medical Sciences, Jeddah 21461, Saudi Arabia

Anas Jarb

Physiological Sciences Department- MBBS program, Fakeeh College for Medical Sciences, Jeddah 21461, Saudi Arabia

References

Shin EC, Jeong SH. Natural History, Clinical Manifestations, and Pathogenesis of Hepatitis A. Cold Spring Harb Perspect Med. 2018 Sep 4;8(9):a031708. doi: 10.1101/cshperspect.a031708. PMID: 29440324; PMCID: PMC6120688.

Abutaleb A, Kottilil S. Hepatitis A: Epidemiology, Natural History, Unusual Clinical Manifestations, and Prevention. Gastroenterol Clin North Am. 2020 Jun;49(2):191-199. doi: 10.1016/j.gtc.2020.01.002. Epub 2020 Mar 29. PMID: 32389358; PMCID: PMC7883407.

Gomella, L. G., & Haist, S. A. (2022). Gomella and Haist’s clinician’s pocket reference. McGraw-Hill Medical.

Cornelissen, C. N., & Hobbs, M. M. (2020). Lippincott Illustrated Reviews: Microbiology. Wolters Kluwer.

Veronese P, Dodi I, Esposito S, Indolfi G. Prevention of vertical transmission of hepatitis B virus infection. World J Gastroenterol. 2021 Jul 14;27(26):4182-4193. doi: 10.3748/wjg.v27.i26.4182. PMID: 34326618; PMCID: PMC8311536.

Kim, B. K., Revill, P. A., & Ahn, S. H. (2011). HBV genotypes: Relevance to natural history, pathogenesis and treatment of chronic hepatitis B. Antiviral Therapy, 16(8), 1169–1186. https://doi.org/10.3851/imp1982

Lin CL, Kao JH. Hepatitis B virus genotypes and variants. Cold Spring Harb Perspect Med. 2015 May 1;5(5):a021436. doi: 10.1101/cshperspect.a021436. PMID: 25934462; PMCID: PMC4448583.

Nevola R, Beccia D, Rosato V, Ruocco R, Mastrocinque D, Villani A, Perillo P, Imbriani S, Delle Femine A, Criscuolo L, Alfano M, La Montagna M, Russo A, Marfella R, Cozzolino D, Sasso FC, Rinaldi L, Marrone A, Adinolfi LE, Claar E. HBV Infection and Host Interactions: The Role in Viral Persistence and Oncogenesis. Int J Mol Sci. 2023 Apr 21;24(8):7651. doi: 10.3390/ijms24087651. PMID: 37108816; PMCID: PMC10145402.

Krajden M, McNabb G, Petric M. The laboratory diagnosis of hepatitis B virus. Can J Infect Dis Med Microbiol. 2005 Mar;16(2):65-72. doi: 10.1155/2005/450574. PMID: 18159530; PMCID: PMC2095015.

Tibbs C. J. (1995). Methods of transmission of hepatitis C. Journal of viral hepatitis, 2(3), 113–119. https://doi.org/10.1111/j.1365-2893.1995.tb00016.x

Laugi H. (2020). Discovery of Hepatitis C Virus: 2020 Nobel Prize in Medicine. Euroasian journal of hepato-gastroenterology, 10(2), 105–108. https://doi.org/10.5005/jp-journals-10018-1326

Karmochkine, M., Carrat, F., Valleron, A. J., & Raguin, G. (1998). Modes de transmission du virus de l'hépatite C [Transmission modes of hepatitis C virus]. Presse medicale (Paris, France : 1983), 27(18), 871–876.

Serfaty L. (1999). Modes de transmission non transfusionnelle et non par toxicomanie intra-veineuse du VHC [Non-transfusional and non-intravenous drug addiction related transmission of hepatitis C virus]. Presse medicale (Paris, France: 1983), 28(21), 1135–1140.

Tibbs C. J. (1995). Methods of transmission of hepatitis C. Journal of viral hepatitis, 2(3), 113–119. https://doi.org/10.1111/j.1365-2893.1995.tb00016.x

Chigbu, D. I., Loonawat, R., Sehgal, M., Patel, D., & Jain, P. (2019). Hepatitis C Virus Infection: Host⁻Virus Interaction and Mechanisms of Viral Persistence. Cells, 8(4), 376. https://doi.org/10.3390/cells8040376

Kumar, V. (2018). Liver and Gallbladder. In Robbins basic pathology (pp. 645–646). essay, Elsevier.

Negro F, Korba BE, Forzani B, Baroudy BM, Brown TL, Gerin JL, Ponzetto A. Hepatitis delta virus (HDV) and woodchuck hepatitis virus (WHV) nucleic acids in tissues of HDV-infected chronic WHV carrier woodchucks. J Virol. 1989 Apr;63(4):1612-8.

Ni Y, Lempp FA, Mehrle S, Nkongolo S, Kaufman C, Fälth M, Stindt J, Königer C, Nassal M, Kubitz R, Sültmann H, Urban S. Hepatitis B and D viruses exploit sodium taurocholate co-transporting polypeptide for species-specific entry into hepatocytes. Gastroenterology. 2014 Apr;146(4):1070-83.

Niro GA, Smedile A, Andriulli A, Rizzetto M, Gerin JL, Casey JL. The predominance of hepatitis delta virus genotype I among chronically infected Italian patients. Hepatology. 1997 Mar;25(3):728-34.

Wu JC, Choo KB, Chen CM, Chen TZ, Huo TI, Lee SD. Genotyping of hepatitis D virus by restriction-fragment length polymorphism and relation to outcome of hepatitis D. Lancet. 1995 Oct 07;346(8980):939-41.

Borghesio E, Rosina F, Smedile A et al. Serum immunoglobulin M antibody to hepatitis D as a surrogate marker of hepatitis D in interferon-treated patients and in patients who underwent liver transplantation. Hepatology27,873–876 (1998).

Zachou K, Yurdaydin C, Drebber U et al. Quantitative HBsAg and HDV-RNA levels in chronic delta hepatitis. Liver Int.30(3),430–437 (2010). • HBsAg levels correlate with HDV viremia in chronic HDV. Biochemical parameters do not accurately indicate the stage and grade of liver disease in chronic HDV.

Smedile A, Niro MG, Rizzetto M. Detection of serum HDV-RNA by RT-PCR. In: NJ Methods in Molecular Medicine, Vol 95: Hepatitis B and D Protocols. Hamatake RK, Lau JYN (Eds). Totowa: Humana Press Inc., NJ, USA, 85–93 (2004).

Takakusagi S, Kakizaki S, Takagi H. The Diagnosis, Pathophysiology, and Treatment of Chronic Hepatitis E Virus Infection-A Condition Affecting Immunocompromised Patients. Microorganisms. 2023 May 16;11(5):1303. doi: 10.3390/microorganisms11051303. PMID: 37317277; PMCID: PMC10220693.

Wu X, Chen P, Lin H, Hao X, Liang Z. Hepatitis E virus: Current epidemiology and vaccine. Hum Vaccin Immunother. 2016 Oct 2;12(10):2603-2610. doi: 10.1080/21645515.2016.1184806. Epub 2016 May 16. PMID: 27184971; PMCID: PMC5085000.

Lin S, Zhang YJ. Advances in Hepatitis E Virus Biology and Pathogenesis. Viruses. 2021 Feb 9;13(2):267. doi: 10.3390/v13020267. PMID: 33572257; PMCID: PMC7915517.

Prasidthrathsint K, Stapleton JT. Laboratory Diagnosis and Monitoring of Viral Hepatitis. Gastroenterol Clin North Am. 2019 Jun;48(2):259-279. doi: 10.1016/j.gtc.2019.02.007. Epub 2019 Apr 1. PMID: 31046974; PMCID: PMC10461253.

Wu X, Chen P, Lin H, Hao X, Liang Z. Hepatitis E virus: Current epidemiology and vaccine. Hum Vaccin Immunother. 2016 Oct 2;12(10):2603-2610. doi: 10.1080/21645515.2016.1184806. Epub 2016 May 16. PMID: 27184971; PMCID: PMC5085000.