Broncho-Relaxant, Anti-Inflammatory and Mast Cells Stabilisation Effects of Successive Extracts of BarleriaCristata Whole Plant
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Abstract
B. cristata ns L. is a ethno medicinal plant used for various pharmacological potentials. B. cristata have been traditionally claimed for its usefulness against cough and bronchitis by means of using of decoction of roots, leaves, or whole plant. In this research an evaluation of successively obtained extracts from whole plant of B. cristata were evaluated for the mast cell stabilisation, anti-inflammatory, anti-oxidant and broncho-relaxant effects against Ach-induced contraction. The obtained results revealed that the tracheal contraction induced by the Ach was markedly relaxed by B. crsitata with maximum relaxation, at the dose of 0.8 mL. Additionally, extract exhibited mast cell stabilisation effect by decrease in histamine release of 13.96 in compound 48/80 induced destabilisation at 50 mg/ml. The BCW-ET extract exhibited not only better relaxant activity on isolated tracheal rings, but also revealed good phytochemical profile, anti-oxidant and anti-inflammatory effect. More detailed studies are needed to identify the target of the inhibition, and to determine precise pharmacological mechanisms of observed biological effects.
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