In Vitro Evaluation of Certain 6-Hetero Aryl-5-Hexene-2,4-Diones and Their Metal Complexes for Cytotoxic Activity

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Published: Jun 10, 2022
DOI: https://doi.org/10.53555/jaz.v43i1.3664
Keywords:
ML2 stoichiometry, IR spectra, 1 H NMR; Mass, Complexation, Dalton’s Lymphoma Ascites Cell lines, Cytotoxicity

Main Article Content

Manju R
K. Kannan

Abstract

A series of 6-Hetero aryl-5-hexene-2, 4-diones (1a-b) and their Cu (II) complexes (1c-d) of ML2 stoichiometry were synthesized by condensation of heterocyclic aldehydes with acetyl acetone through boric anhydride mediated mechanism. Boric anhydride act by blocking the medial methylene group of acetyl acetone and provides a new pathway other than facile Knoevenagel condensation. All the final structures were assigned on the basis of IR, 1H NMR and mass spectra analysis. The test compounds were studied for short term in vitro cytotoxicity using Dalton’s Lymphoma Ascites cell lines (DLA). The compound code 1c and 1d found to show significant cytotoxic action.


 

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How to Cite
Manju R, & K. Kannan. (2022). In Vitro Evaluation of Certain 6-Hetero Aryl-5-Hexene-2,4-Diones and Their Metal Complexes for Cytotoxic Activity. Journal of Advanced Zoology, 43(1), 426–431. https://doi.org/10.53555/jaz.v43i1.3664
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Vol. 43 No. 1 (2022): Volume 43 No 01 (2022)
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Articles
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This work is licensed under a Creative Commons Attribution 4.0 International License.

Author Biographies

Manju R

Research Scholar, Department of Pharmacy, Faculty of Engineering and Technology, Annamalai University, Annamalai Nagar-608 002, Chidambaram, Tamilnadu, India

K. Kannan

Department of Pharmacy, Faculty of Engineering and Technology, Annamalai University, Annamalai Nagar-608 002, Chidambaram, Tamilnadu, India

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