Improving Treatment-Diagnostic Measures Aimed At Identifying And Correcting Low Or High Levels Of Homocysteine
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Abstract
Homocysteine is a sulfur-containing amino acid that is synthesized from methionine under physiological conditions. Normally, the concentration of homocysteine in the blood serum is 5 - 15 µmol/l. During life, the average level of homocysteine can increase by 3 - 5 µmol/l. A serum homocysteine level of more than 16 µmol/l significantly increases the risk of developing cardiovascular diseases. The role of elevated homocysteine levels in the development of endothelial dysfunction and thrombophilic conditions, which are one of the key factors in the development of fetal loss syndrome at different stages of gestation, is described. This article examines homocysteine-related placental and reproductive processes.
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References
Litvinenko, I.V. Hyperhomocysteinemia in Par's disease Kinson - a new variant of the complications of the therapy or a specific marker of the disease? / I.V. Litvinenko [et al.] // Annals of the wedge and experiment. nevrol . - 2018. - V. 2, No. 2. - S. 13-17.
Lobzin, V. Yu. Cerebral Metabolism Assessment 18fluorodeoxyglucose in the early diagnosis of cognitive impairments / V. Yu. Lobzin [et al.] // Medline.ru. - 2013. - V. 14, No. 1. - S. 1057-1070.
Polushin, A.Yu. Hyper homocysteinemia is a predictor of severity stroke against the background of extensive damage to the medulla / A.Yu. Polushin [and others] // Vestn. Ross. military-med. acad. - 2013. - No. 4 (44). - S. 89-94.
Allen, LH Causes of vitamin B12 and folate deficiency / LH Allen// Food Nutr. Bull. - 2018. - Vol. 29. - S. 20-34.
Hooshmand, B. Homocysteine and holo-transcobalamin and therisk of Alzheimer disease: a longitudinal study / B. Hooshmand [et al.] // Neurology. - 2010. - Vol. 75. - P. 1408-1414.
Morris, MS Folate and vitamin B-12 status in relation to anemia, macrocytosis and cognitive impairment in older Americans in the age of folic acid fortification / MS Morris [et al.] // Am. J. Clin. Nutr. - 2017. - Vol. 85. - P. 193-200.
Nilsson, K. Plasma homocysteine is elevated in elderly patients with memory complaints and vascular disease / K. Nilsson, L. Gustafson, B. Hultberg // Dement. Geriatr .Cogn .Discord . - 2007. - Vol . 23. - P. 321-326.
Nurk, E. Plasma total homocysteine and memory in the elderly: the Hordaland homocysteine study / E. Nurk [et al.] // Ann. Neurol. - 2005. - Vol . 58.-P 847-857.
Prins, ND Homocysteine and cognitive function in the elderly: the Rotterdam Scan Study / ND Prins [et al.] // Neurology. - 2002. - Vol. 59. - P. 1375-1380.
Dhobale MV, Pisal HR, MehendaleJoshi SR Differential expression of human placental neurotrophic factors in preterm and term deliveries. Int. J. Dev. Neurosci. 2013; 31(8): 719-23. https://doi . org /10.1016/j.ijdevneu.2013.09.006
Garces MF, Sanchez E., Torres-Sierra AL, Ruiz-Parra AI, Angel-Muller E., Alzate JP, Sanchez AY, Gomez MA, RomeroC., Castaneda ZE, Sanchez- Rebordelo E., Dieguez C., Nogueiras R., Caminos JE Brain-derived neurotrophic factor is expressed in rat and human placenta and its serum levels are similarly regulated throughout pregnancy in both species. Clinic .Endocrinol .( Oxf .). 2014; 81(1): 141-51. https://doi.org/10.1111/cen.12391
Tometten M., Blois S., Arck PC. Nerve growth factor in reproductive biology: link between the immune, endocrine and nervous system? Chem .Immunol . Allergy 2005; 89:135-48. https://doi . org /10.1159/000087962