Study the Serum Levels of IL-17, IL-23, TLR-4, and TLR-7 Role in Immunopathogenesis in Patients with Moderate and Severe Psoriasis

Abstract

Objective: Psoriasis is an immune-mediated disease* (a disease with an unclear cause that is characterized by inflammation caused by dysfunction of the immune system) that causes inflammation in the body. This study examined the relationship between immunological markers (IL-17 and TLR-4) and several socio-demographic parameters, including age, sex, disease severity, stress, smoking behaviours, BMI classification, and dietary preferences, in patients with psoriasis. Methods: Psoriasis on patients at the Imam Al-Hussein City Hospital in Karbala Province, Iraq, psoriasis from December 2022 to April 2023. The participants were healthy individuals and newly diagnosed, untreated psoriasis patients. Pregnant women, those with chronic conditions, and those receiving psoriasis medication were excluded. A case-control observational study was conducted, using convenience sampling to select participants. The PASI scoring method was used to evaluate four body areas, and the sandwich ELISA method was used for immunomarker analysis. Results: The study found significant dispirited in the severity of psoriasis among individuals, with 54.44% presenting with intermediate symptoms and 45.56% showed severe manifestations. The moderate and severe psoriasis patients were classified into five age cohorts. The severity of psoriasis correlates with age, with those with severe psoriasis being older. Socio-demographic features revealed a greater prevalence of moderate patients than those with severe psoriasis. The study also found a significant association between greater BMI values and severe symptoms, smoking behaviours, elevated stress levels, and higher consumption of processed foods. Immunological markers such as IL-17, IL-23, TLR-4, and TLR-7 were also examined, showed significant variations between control participants and those with moderate and severe forms of the condition. These findings contributed to understanding the determinants impacting psoriasis severity and its clinical implications for patient care and therapeutic interventions. Conclusion: Psoriasis patients make up a significant part of the study population, with higher smoking, stress, and healthy food habits. There was no significant difference in BMI, disease severity. of immunological markers IL-17, IL-23, TLR-4, and TLR-7 showed a significantly increase.