THE ROLE OF GENETIC DETERMINANTS IN THE OCCURRENCE OF HYPERPLASTIC PROCESSES OF THE REPRODUCTIVE SYSTEM OF WOMEN’S MENOPAUSAL AGE

Abstract

When analyzing the allelic distribution of the GPITIa gene in women with endometrial hyperplastic processes compared with the population, the following was revealed: when using the method of observed and expected frequencies in patients with endometrial hyperplastic processes, the distribution of alleles of the GPIIIa gene statistically differs from the population (p<0.05), due to an increase in frequency occurrence of the PLA1A2 genotype; - when analyzing the allelic distribution of the GPIIIa gene in patients with endometrial polyps, there were no statistically significant changes in the allelic distribution of the GPIIIa gene compared to the population frequencies. However, the PLA1A2 genotype of the GPIIIa gene is statistically significantly more common in patients: with recurrent endometrial polyps (p<0.05).