Design and evaluation of Moringa oleifera loaded transferosome vesicles: In vitro characterization

Abstract

Moringa oleifera  herb is widely found in western ghat. The anticancer potential especially against breast cancer is proved by many scientific investigators. However poor skin permeability of active constituents limits the therapeutic use of this herbal active. Transfersomes are modified liposomes with improve skin permeation ability. Thus, extract loaded transfersomes were formulated to improve skin permeation of extract. The transfersomes are phospholipid based vesicles with edge activators. The edge activators increase skin permeation of transfersomes. The extract loaded transfersomes were fabricated using thin film hydration and assessed for vesicle size, microscopic imaging and thermal behavior. The transfersomes showed acceptable vesicle size and zeta potential. Thus, formulated transfersomes could be promising alternative for skin permeation enhancement of herbal active.