Formulation Develoment And Evaluation Herbal Effervescent Floating Tablet By Using Syzygium Cumini Seed Extract Used In Treatment Of Diabetes
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Abstract
Background: Floating tablets prolong the gastric residence time of drugs, improves bioavailability, and facilitate local drug delivery to the stomach. With this objective, floating tablets containing extract of Syzgium cumini seed extract as active ingredient was prepared for the treatment of antidiabetic.
Material and method: Floating tablets of Syzgium cumini seed extract were prepared by direct compression method using Magnesium stearate, Microcrystalline cellulose, Citric acid and Sucrose. The formulations were evaluated for various physical parameters, floating lagtime.
Result: The thickness was in the range 4.02-4.086 mm. The hardness ranged from 3.1-3.3 kg/cm2, All formulations passed the USP requirements for friability and uniformity of weight. The buoyancy time of all tablet formulations was less than 5min and tablet remained in floating condition throughout the study.
Conclusion: The optimized formulation was found to be F5 batch which released 98.13% of drug in 8hr invitro, while the floating lag time was 92 seconds.
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