FORMULATION AND EVALUATION OF LAMOTRIGINE BASED SELF-NANO EMULSIFYING DRUG DELIVERY SYSTEM

Abstract

Self-nanoemulsionof Lamotrigine (LMT), an anti-epileptic agent, having poor solubilty was formulated to improve the solubility and permeation. Co surfactant like Ethyl Oleate, Caprylate, Eucalyptus oil, Caprylic, Corn oil, Capmule, Fish oil, Coconut oil whereas PEG 400 and Propylene glycol to form the oil phase was selected as the oil. Seven trials were done using combination of sufactants/co-surfactants with oil phase . Trial H containing Caprylate as oil phase at Smix1:1(Tween20/PEG400, 1:1) proportion and trial I, the oil phase [Caprylate] composition was changed from Smix 1:1 to Smix (Tween20/PEG400, 1:2) formulated as SNEDDs and phase diagram shows 1:1 system is suitable for formulation . Aqueous dilution test shows that it is found for 3 hour gradually turbid on staying. Since it immediately dissolve the drug as a result of solubilisation effect of surfactant present in formulation. Stability study was carried out at 25o C/ 75 Rh. In this method no change in consistency, Colour or appearance has been observed. In vitro drug release was found to be identical in the formulations stored before after placed on stability. It appeared that the formulation of the selected batches kept on the stability test was found to be stable. In accelerated stability evaluation showed that Self nano-emulsion follows 1st order kinetic and found to be stable